Chronic pancreatitis and the intestinal microbiome in adults and children: Not only SIBO but also gut dysbiosis has clinical significance

Chronic pancreatitis is accompanied by both small intestinal bacterial overgrowth and dysbiosis of the gut microbiota. The most typical changes in microbiota chronic are a decrease microbial diversity, an increase abundance Proteobacteria, Bacteroidetes, Actinobacteria, Firmicutes, especially butyrate-producing bacteria such as Faecalibacterium , significant association with infectious pathways (KEGG analysis]), concomitant metabolic disorders (diabetes mellitus) exocrine pancreatic insufficiency. Changes children like those adults characterized α-diversity loss shortchain fatty acid producers: Subdoligranulum Eubacterium propionate-producing Phascolarctobacterium acetate- lactate-producing Collinsella probiotic Bifidobacterium . Dysbiotic microbiome, including commensal symbionts, significantly associated severity pancreatitis. important factor influencing function, which leads to switch from enterotype 1 ( Bacteroides predominance) 2 Prevotella phylogenetic diversity (α-diversity index). Modulation dysbiotic can be carried out probiotics, prebiotics, metabolites butyrate, enzymes should become full-fledged therapeutic option patients